APPLICATION OF AN R-GROUP SEARCH TECHNIQUE IN THE MOLECULAR DESIGN OF DIPEPTIDYL BORONIC ACID PROTEASOME INHIBITORS

Application of an R-group search technique in the molecular design of dipeptidyl boronic acid proteasome inhibitors

In this work, a 3D-QSAR model involving for 40 dipeptidyl boronic acid proteasome inhibitors was built based on Topomer CoMFA.The multiple correlation coefficient of fitting, cross-validation and external validation were 0.908, 0.647 and 0.703, respectively.The results indicated that the obtained Topomer CoMFA model has not only the favourable esti

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Peer review of the pesticide risk assessment for the active substance cyflumetofen in light of confirmatory data submitted

Abstract The conclusions of EFSA following the peer review of the initial risk assessment carried out by Litter Accessories the competent authority of the rapporteur Member State, the Netherlands, for the pesticide active substance cyflumetofen are reported.The context of the peer review was that requested by the European Commission following the s

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